A young petty criminal, Lee, wakes in a seedy motel to find a bullet in his side and a suitcase of stolen money next to him, with only the haziest memory of exactly how he got there. Soon he meets Dr. Wild, a morphine-addicted doctor who is escaping his own disastrous life. The two men form an unwilling, unlikely alliance and set out for the safety of a country estate owned by a former colleague of Wild's named Sherman.
As they flee the city, they develop an uneasy intimacy, inevitably revisiting their pasts even as they desperately seek to evade them. Lee is haunted by a brief stint in jail, while Wild is on the run from the legacy of medical malpractice. But Lee and Wild are not alone: they are pursued through an increasingly alien and gothic landscape by the ageing gangster Josef, who must retrieve the stolen money and deal with Lee to ensure his own survival. By the time Josef finally catches up to them, all three men have been forced to confront the parts of themselves they sought to outrun.