He is best known for combining medical writing with the thriller genre. Several of his books have been bestsellers on the "New York Times" Bestseller List. Several of his books have also been featured in Reader's Digest.
Cook's novels have anticipated national controversy. Interviewer Stephen McDonald talked to him about his novel Shock; Cook admits the timing of Shock was fortuitous. "I suppose that you could say that it's the most like Coma in that it deals with an issue that everybody seems to be concerned about," he says, "I wrote this book to address the stem cell issue, which the public really doesn't know anything about. Besides entertaining readers, my main goal is to get people interested in some of these issues, because it's the public that ultimately really should decide which way we ought to go in something as ethically questioning as stem cell research."