Protecting-group-free Organic Synthesis - Improving Economy and Efficiency

This book presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for and future prospects of protecting-group-free synthesis. Following this the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis of glyco-conjugates, peptides and biopolymers, and protecting-group-free synthesis of synthetic materials. The book concludes with chapters on nature-inspired and biomimetic protecting-group-free synthesis, and latent functionality as a tactic toward formal protecting-group-free synthesis.
This book aims to support synthetic chemists in the design of strategies which avoid or minimize the use of protecting groups, so as to come closer to achieving an tsquo;ideal synthesisasquo; and supporting the global need of practicing green chemistry.