As the giant Boeing 747 lifts majestically into the darkening sky above Frankfurt, the 245 passengers on Flight 66 are looking forward to Christmas celebrations a few hours away on the other side of the Atlantic.
But when a passenger keels over with an apparent heart attack, the aircraft is mysteriously refused permission to land at Heathrow . . . or back at Frankfurt . . . or even at Amsterdam's Schiphol. For the sick man is infected with a deadly virus capable of wiping out entire populations, and the passengers and crew of Flight 66 now find themselves on a nightmare journey with no end in sight.
As panic escalates on board and an unidentified aircraft starts to shadow them, can a safe haven be found before Flight 66 is destroyed?