His literary works were usually based on the action genre and heavily feature technology. His novels epitomised the techno-thriller genre of literature, often exploring technology and failures of human interaction with it, especially resulting in catastrophes with biotechnology. Many of his future history novels have medical or scientific underpinnings, reflecting his medical training and science background. He was the author of The Andromeda Strain, Congo, Disclosure, Rising Sun, Sphere, Timeline, State of Fear, Airframe, Prey, Next (the final book published before his death), Pirate Latitudes (to be published November 24, 2009), a final unfinished techno-thriller to be released sometime in the fall of 2010, and Travels.