Nancy Skidmore has Alzheimer’s and her oldest friend Eugene Chaney III once more a purpose in life – to end hers. When the moment for Gene to take Nancy to her desired death in Coffeeville arrives, she is unexpectedly admitted to the secure unit of a nursing home and he has to call upon his two remaining friends to help break her out: one his godson, a disgraced weatherman in the throes of a midlife crisis, and the other an ex-army marksman officially dead for forty years.
On a tour bus once stolen from Paul McCartney, and joined by a young orphan boy searching for lost family, the band of misfits career towards Mississippi through a landscape of war, euthanasia, communism, religion and racism, and along the way discover the true meaning of love, family and – most important of all – friendship. Charming, uplifting and profoundly moving, Last Bus to Coffeeville is a chronicle of lives that have jumped the tracks; a tale of endings and new beginnings; a funny story about sad things.