Flint Lockwood and the rest of the Cloudy with a Chance of Meatballs gang are back in an all-new adventure. Everyone in Swallow Falls is celebrating Flint Lockwood's defeat of his food-creating machine, the FLDSMDFR, when the world-famous inventor and Flint's idol, Chester V, turns up.
Chester V offers the use of his Thinkquanauts to help clean up the island. Flint is thrilled, but it seems that cleaning up Swallow Falls is proving very complicated. The FLDSMDFR is still working and creating all sorts of living food animals that are attacking Chester V's clean-up crew. Flint must help Chester V to destroy the FLDSMDFR once and for all so Swallow Falls can return to normal life.
Will Flint rise to his idol's expectations or will it become clear that things on the island aren't what they seem and that there's something a little fishy about Chester V?