Chasers heralds the return of the Apaches - a cadre of controversial former NYPD cops first introduced in Carcaterra's previous novel, Apaches. In this sequel, set three years later, the surviving members of the team reunite to continue their relentless battle against crime.
Their new adventure is kick-started by the machine-gun murder of innocent bystanders in a Manhattan restaurant, one of whom happens to be Boomer's neice. Boomer, Dead Eye and Reverend Jim reunite to hunt down the Colombian drug cartel responsible. Joining the group in this mission are three new Apaches: Ash, a wounded female Hispanic cop with a speciality in arson investigations; Quincy, an HIV-positive recruit who specialises in forensics; and the ironically-named Buttercup, a retired police dog who is a gold-shield detective, highly decorated for her skills at sniffing out illegal drugs. It's the Apaches versus the drug lords in an all-out New York City street war.