Increasing recognition of healthcare disparities and unique health needs of LGBTQ2S peoples calls for a revitalization of health professional training programs. As new topics become integrated into these programs, there is a great need for a comprehensive resource that aligns with Canadian guidelines and standards of care.Caring for LGBTQ2S People identifies gaps in care and health care disparities, and provides clinicians with both the knowledge and the tools to continue to improve the health of LGBTQ2S people. Written by expert authors, many with lived experiences, this fully updated version builds on the critically praised first edition and highlights the significant social, medical, and legal progress that has occurred in Canada since 2003. The book includes general medical information, and guidance that is useful for anyone providing care to LGBTQ2S people. Chapters begin with the fundamentals of language, cultural competency, and the patient-provider relationship. This edition includes contemporary and expanded chapters on STIs, HIV, substance use, mental health, fertility, and trans health, and concludes with unique considerations for those who experience an intersection of diverse identities. Written for a general and trainee-level reader in health care and primary care, this clinical guide provides a comprehensive understanding of LGBTQ2S health.